- Does it infect other primates?
- Pathogenicity picture explain more?
Note the picture:
- Endocytosis- Shigella gets into enterocyte
- Enclosed by vacuole
- Break out from vacuole
- Propagate in cell
- Cell secretes cytokines
- Cytokines attract PMN
- PMN opens up tight junctions between enterocytes
- Damage enterocyte layer
- Shiga toxin from Shigella gets into blood
- Damage blood vessels
- Blood diarrhea and systemic symptoms
Not in exact sequence, e.g., shiga toxin can be produced any time
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